Synthesis, Characterization and Antibacterial Activity Study of New-Aminonitrile Complexes with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) Metal Ions
DOI:
https://doi.org/10.22401/ANJS.28.4.01Keywords:
Anti-bacterial activity, α-aminonitrile, Bidentate, ComplexesAbstract
Several metal ion complexes of manganese (II), cobalt (II), nickel (II), copper (II) and zinc(II) were derived from (E)-2-(2-hydroxyphenyl)-2-((4-(phenyldiazenyl)phenyl)amino)acetonitrile ligand (L) and have been characterized using conventional techniques such as 1H and 13C-NMR, FT-IR and UV-VIS spectroscopy, elemental analysis, thermal analysis, flam atomic absorption and molar conductivity. The five new complexes were suggested to be of octahedral geometry and were observed to be electrolytic. The coordination pattern of the ligand was bidentate of NO-type through amine and hydroxyl groups forming stable 6-membered ring releasing nitrile group free. [ML2(H2O)2]Cl2.XH2O is the suggested general formula for the complexes that M: manganese (II), cobalt (II), nickel (II), copper (II) or zinc (II)], X = 1, 4, 2, 4 or 1 respectively, hence that each metal interacted with two ligands and two aqua molecules. All the complex compounds and the ligand were investigated for anti-bacterial activity against four bacterial genera including: Pseudomonas spp., Escherichia coli, Proteus spp. and Staphylococcus aureus. The antibacterial activity results were promising, that they ranged from 11mm to 21mm, especially the L against Escherichia coli and Staphylococcus aureus bacteria, meanwhile, the complexes showed very good inhibition zones against the gram positive bacteria only, except Ni(II) and Zn(II) complexes showed no activity against Escherichia coli. Generally, the activity was suggested due to taking in account the presence of nitrile moiety, beside complex form that possesses metal ion. The aim of this work is to design a chelating α-aminonitrile ligand to interact with some transition element salts to produce the corresponding complexes and to investigate their activities against selected bacteria.
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